|Prolonged fever is a difficult to diagnose febrile disorder appositely termed Fever of Unknown Origin (FUO). Fever of unknown origin was first termed prolonged and perplexing fevers by Kiefer and Leard and may be defined as disorders with temperatures greater than 38.3Â°C (101Â°F) on several occasions with a duration of fever greater than three weeks that were not diagnosed after one week of intensive in-hospital investigation.
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