Melanin is the main pigment responsible for skin, eye, and hair color. Variation in a number of genes, including the melanocortin 1 receptor (MC1R), agouti-signaling protein (ASIP), oculocutaneous albinism 2 (OCA2), solute-carrier transport protein 45A2 (SLC45A2), and solute-carrier transport protein 24A5 (SLC24A5), have been associated with pigmentation. Functional and bioinformatics analyses support the biological role of variants (rs1805007, rs2424984, rs12913832, rs16891982, and rs1426654) associated with these genes.
Most common skin discoloration in North-East is Vitiligo, an acquired familial non- neoplastic depigmentary disorder of skin, hair. Due to selective destruction of melanocytes, which subsequently destroyed and affected area turns pale and becomes white. Evidence of clinical association of vitiligo with AID of organs like pernicious anemia, thyroid disease, IDDM
Scholarly journals are generally academic journals that encourage academic and scientific research. These journals generally prefer to publish original works, conducted following a systematic research methodology. The articles published in the scholarly journals are critically evaluated following in-depth analysis of the research data. Scholarly Journal articles strictly adhere to a standard format of writing. Once the author accomplishes their task of writing following the standard format and submits the manuscript for publication, it is the responsibility of the scholarly journal to verify whether it is written as per the academic and research norms.
Last date updated on June, 2014