It is widely accepted that adipose tissue is a highly dynamic endocrine organ that secretes more than 600 bioactive substances termed âadipokinesâ and plays an essential role in regulating insulin sensitivity, energy metabolism and vascular homeostasis. It has become clear that obesity promotes a state of chronic low-grade systemic inflammation in WAT. This chronic inflammation is deeply involved in IR, which is the underlying condition of T2DM and Metabolic Syndrome. An inflammatory state develops in response to excessive nutrient influx into metabolic tissues including adipose tissue, liver, and skeletal muscle and is currently recognized as an important link between obesity and IR.
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Last date updated on October, 2020