"Mophogenic effect has been also demonstrated after exposure of human glioblastoma cells to flavonoids. Exposure of GL-15 cell to rutin and penduletin also induced changeson pattern of expression of cytoskeletal proteins with reduction on expression of nestin and vimentin, and increase on expression of GFAP, a marker of astrocytes, suggesting induction of astroglialdifferentiation. Nestin is Vimentin is the major cytoskeletalcomponent of immature astrocytes and GFAP is a major protein of astrocytes intermediate filaments and a specific marker for these cells.
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Citation: Costa SL (2014) Antiglioma Potential of Flavonoides. J Bioanal Biomed 6: e124."
Last date updated on July, 2014