Mucinous Neoplasm

Fatty Acid Synthase (FAS) is usually expressed in hormonesensitive cells and cells showing high-level lipid metabolism in animals. FAS increases the de novo biosynthesis of fatty acids, which contributes to cellular activities including energy metabolism,building cellular membranes, and intracellular second messengers. FAS expression is suppressed in normal cells because serum fatty acids are usually rich in the diet. In cancer cells and preneoplastic lesions, FAS expression has been found to be up-regulated. It has been suggested that FAS contributes to tumorigenesis because it’s over expression has been demonstrated in precancerous lesions and early cancers using immunohistochemical staining. IPMN is considered to be one of the precancerous lesions of pancreatic ductal adenocarcinoma. In the 2010 WHO classification, IPMNs are classified as showing low-, intermediate-, or high-grade dysplasia on the basis of the degree of architectural and cytological atypia identified. Previously, Walter et al. reported that FAS tissue expression in 30 cases of IPMN was correlated with the histologic grade. However, differences in FAS expression among histological subtypes of IPMN, such as the gastric, intestinal, and pancreatobiliary types have not been fully discussed. In this report, we examined the differences of FAS expression among subtypes of IPMN resected in our department using immunohistochemistry.

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Last date updated on May, 2024