MS is a complex, multifactorial disease. Data suggests MS is a two-phase disease. The early phase is predominantly inflammatory/demyelinating and the secondary/progressive phase is neurodegenerative. However, many studies show that neuronal and axonal damage are present in early phases of MS, suggesting mechanisms of neurodegeneration contribute to MS pathogenesis throughout the disease. Recent studies have unveiled that immune responses to non-myelin target antigens contribute to neurodegeneration and the pathogenesis of MS. Considering there are no effective therapies for progressive forms of MS, a comprehensive understanding of antibody mediated mechanisms of neurodegeneration in MS should lead to novel therapeutic agents to treat it, and thus, reduce disability Levin MC, Lee S, Gardner LA, Shin Y, Douglas JN, et al. Autoantibodies to Non-myelin Antigens as Contributors to the Pathogenesis of Multiple Sclerosis.
Journal of multiple sclerosis is a journal of high interest to MS health-care professionals. The journal is a bipartite journal focusing on clinical aspects of multiple sclerosis as well as rehabilitation. Journal topics include rehabilitative, nursing, neurological, psychological, and psychosocial care etc. The journal articles are mainly focusing on the life issues of people with MS. Thus we are trying to approach and reflect various difficulties in MS patients and thus urging for a cure.
Last date updated on June, 2014