âMS is an autoimmune demyelinating disease of the CNS with multifactorial etiology. Demyelation causes loss of nerve signals, which in turn results in many clinical manifestations (e.g. visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction). The development of MS might involve epigenetic changes, which are passed from parent to offspring, and are highly sensitive to environmental influences, such as smoking or vitamin D deficiency. These epigenetic mechanisms include DNA methylation, histone modification and microRNA-associated post-transcriptional gene silencing. Moscarello et al. proposed that myelin damage in MS white matter results from a failure to maintain the myelin sheath, due to enhanced citrullination of MBP. In approximately 18% of the MBP molecules of healthy adult humans, 6 out of 19 arginines are citrullinated (MBP-cit6: R25, R31, R122, R130, R159, R267). The remaining MBP molecules do not contain citrulline. In MS patients, the proportion of MBP-cit6 is increased to 45% of total MBP Chirivi RGS et al., Citrullination: A Target for Disease Intervention in Multiple Sclerosis and other Inflammatory Diseases?.
Journal of multiple sclerosis is an upcoming journal started in the year of 2014 focussing on multiple sclerosis, related cases and on-going research in this field of medicine.
Last date updated on September, 2020