âAs a disease of the central nervous system, multiple sclerosis (MS) is the leading cause of non-traumatic neurological disability in young adults, affecting more than two million people worldwide. Although the pathogenesis of the disease is not yet fully understood, hemodynamic abnormality and disruption of white matter (WM) integrity are associated with the pathological processes and contribute to the appearance of MS lesions.
Accumulating data show that MS discrete lesions do not instantly emerge, but gradually develop, and eventually lead to a wide variety of neurological disabilities due to irreversible axonal damage. Classification of the lesions by the severity of tissue injury may provide crucial information for shaping therapeutic goals since the lesion at the chronic stage with extensive axonal loss may be less responsive to current treatments than the lesion at the early stage with inflammation, edema and demyelination of axons. Moreover, identification of lesions with severe tissue destruction could potentially serve as a surrogate marker for characterizing the disease status, which is accompanied with the corresponding clinical disabilityâ Li L et al., Perfusion and Diffusion Abnormalities of Multiple Sclerosis Lesions and Relevance of Classified Lesions to Disease Status.
Journal of multiple sclerosis publishes articles showing the disease progression of multiple sclerosis and the lesion development during the disease.
Last date updated on June, 2014