Journal of Multiple Sclerosis is an open access journal that publishes articles within the scope of multiple sclerosis and related disorders. Pediatric multiple sclerosis is one of the common neurocognitive disorder seen in children under the age of 10. Journal publishes articles that deal with causes of multiple sclerosis susceptibity in children.
âMultiple sclerosis (MS) is a chronic autoimmune demyelinating disease of the central nervous system (CNS) of unknown origin. Both environmental and genetic factors have been implicated in the pathogenesis of the disease leading to the well-known consideration of MS as a complex multi-factorial disease entity. Concerning genetics, linkage studies in many populations consistently have showed that the human leukocyte antigens (HLA), products of the Major Histocompatibility Complex (MHC) on chromosome 6p21.3 are linked to MS. MHC represents a cluster of highly polymorphic genes, including the HLA-Class I, II and III genes that encode proteins which serve antigen presentation to T-lymphocytes. Different auto antigens have different binding capacities to HLA molecule, explaining ostensibly the predisposing role of HLA in autoimmune diseases.
MS is mainly a white matter disease, and lesions appear mainly in a peri-ventricular distribution, but the cortex and deep gray matter (GM) nuclei are also affected. MS is active even during remission periods. GM atrophy is independent of the MS lesions and is associated with physical disability, fatigue, and cognitive impairment. The scars that give the name to the condition are produced by the astrocyte cells healing old lesionsâ Anagnostouli MC et al., HLA-DRB1* Allele Frequencies in Pediatric, Adolescent and Adult-Onset Multiple Sclerosis Patients, in a Hellenic Sample. Evidence for New and Established Associations.
Last date updated on July, 2014