Pediatric multiple sclerosis is a disorder that affects the children during the early stage of development. The recent studies and research has found the prevalence of this demyelinating disease is more in female children.
âPatients with early-onset MS (before 18 years old) account for the 3.5- 5 % of the general pool of the MS patients. DRB1*15 association with childhood and or earlier onset of MS has been attested by studies. Moreover, DRB1*04 combined with DRB1*15 has been linked with earlier onset of the disease but it may
delay age at onset when combined with DRB1*0801. In a Korean population, close linkage of DRB3*02, DRB1*13 and DQB1*03 was also associated with the risk of childhood MS. Although the scarcity of MS during adolescence could be attributed to the anti-inflammatory and/or neuroprotective role of both androgens and estrogens which are found increased during this age-period, the interplay between HLA and these hormones and its consequences on autoimmunity have been poorly studied in MSâ. Anagnostouli MC et al., HLA-DRB1* Allele Frequencies in Pediatric, Adolescent and Adult-Onset Multiple Sclerosis Patients, in a Hellenic Sample. Evidence for New and Established Associations.
Last date updated on October, 2020