Pediatric multiple sclerosis is a disorder that affects the children during the early stage of development. The recent studies and research has found the prevalence of this demyelinating disease is more in female children.
ââ¬ÅPatients with early-onset MS (before 18 years old) account for the 3.5- 5 % of the general pool of the MS patients. DRB1*15 association with childhood and or earlier onset of MS has been attested by studies. Moreover, DRB1*04 combined with DRB1*15 has been linked with earlier onset of the disease but it may
delay age at onset when combined with DRB1*0801. In a Korean population, close linkage of DRB3*02, DRB1*13 and DQB1*03 was also associated with the risk of childhood MS. Although the scarcity of MS during adolescence could be attributed to the anti-inflammatory and/or neuroprotective role of both androgens and estrogens which are found increased during this age-period, the interplay between HLA and these hormones and its consequences on autoimmunity have been poorly studied in MSââ¬Â. Anagnostouli MC et al., HLA-DRB1* Allele Frequencies in Pediatric, Adolescent and Adult-Onset Multiple Sclerosis Patients, in a Hellenic Sample. Evidence for New and Established Associations.
Last date updated on September, 2024