Multiple sclerosis (MS) is a chronic and often progressive inflammatory disease that attacks the myelin sheath of the central nervous system (CNS) presenting a special kind of sclerotic lesions. The northern hemisphere has a high prevalence of MS. In this disease, a cell-mediated immune response accounts for discrete plaques of
demyelization at sites throughout the CNS. The pathophysiology is complex and still under investigation. Some consider MS a pathological entity while some consider it a clinical entity. The unknown underlying condition causes damage in two phases. First some MRI-abnormal areas with hidden damage appear in the brain and spine, followed later by leaks in the bloodââ¬âbrain barrier where immune cells infiltrate causing demyelination Mohammad Hosein Kalantar Motamedi et al., Commemorate National Multiple Sclerosis Day (28th of May): Seek Funding for Research.
Chance of this demyelinating disease, multiple Sclerosis is highly diagnosed in patients less than 18 years. Several recent studies have indicated that 5% of the total MS population with is children/ pediatric cases. This cause of this clinically isolated syndrome has not yet been identified. Pediatric MS symptoms includes major disease presentations such as optic nerve, sensory, motor, brainstem, and/or cerebellar disturbance are the presenting symptoms.
Last date updated on July, 2025