|Progressive Multifocal Leukoencephalopathy is a rare disease caused by JC virus infection and thus loss of myelin. Progressive multifocal leukoencephalopathy (PML) is a disorder of the central nervous system caused by the JC virus. The JC virus, a human polyoma virus, is found widespread over the globe. This disease is very closely related to multiple sclerosis. The disease causes one specific lesion in the brain. PML is often considered as a fatal disease of the central nervous system most commonly associated with severe immunodeficiency syndrome.
Review articles are the summary of current state of understanding on a particular research topic. They analyze or discuss research previously published by scientist and academicians rather than reporting novel research results.
Review article comes in the form of systematic reviews and literature reviews and are a form of secondary literature. Systematic reviews determine an objective list of criteria, and find all previously published original research papers that meet the criteria. They then compare the results presented in these papers. Literature reviews, by contrast, provide a summary of what the authors believe are the best and most relevant prior publications.