Murine B cell development is a leading developmental system for the analysis of gene-regulatory networks that orchestrate cell fate choice and lineage commitment. Since progenitor cells and discrete developmental intermediates can be isolated and experimentally manipulated, the lymphoid system is particularly well suited for studies involving epigenetic, transcriptional, and protein networks that control cell fate choice. The analyses of early B cell development are thus highly advanced, as regulatory networks of signaling molecules and transcription factors have been elucidated that endeavor to account for the generation of B lineage progeny from multi-potent progenitors (MPP). Importantly, genetically altered mouse lines that harbor deletions in key B cell development factors exist, enabling ex vivo expansion of cells arrested at discrete points during lymphopoiesis and B cell specification.
Prediction of Gene Activity in Early B Cell Development Based on an Integrative Multi-Omics Analysis- Karen Reddy
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Last date updated on June, 2014