Paratuberculosis is a chronic infectious disease that affects mainly ruminants and is manifested by relapsing diarrhea that leads to loss of weight, and often emaciation and death. The etiologic agent, Mycobacterium Avium subsp Paratuberculosis (MAP) is fastidious and produced visible colonies in vitro often after several months of incubation. Therefore isolation in artificial media is usually performed in specialized laboratories. Molecular tests are being used widely for the detection of MAP but their clinical value is limited by carrier state and intermittent excretion of the pathogen from the affected animals. Notably both may last for several years until the onset of clinical disease. Effectively the control of paratuberculosis of ruminants becomes complicated, which bears significantly in terms of revenue on the farmer due to decreased productivity of the diseased animals and the cost of the protective measures.
Last date updated on August, 2021