|The provision for Mycobacterium tuberculosis to invade into the body is the lung. After inhalation in the site where it is deposited causes a focal infection. Tuberculosis is a disease with deep social and economic roots. The possible reason of highest number of TB cases might low-income with large families, living in deficient housing conditions with dense urban communities. Therefore, people have a high probability of TB infections. The elderly people with diabetes can have high risk of TB. So do people who live in mal health institutions, such as prisons, schools, day nurseries, social shelters, youth correctional facilities, nursing homes for elderly people and People suffering from Acquired Immunodeficiency Syndrome (AIDS) have high risk of TB. In human populations since ancient times Mycobacterium tuberculosis has existed. The pathological and anatomical descriptions of tuberculosis (TB) disease began to appear in the seventeenth century.