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Multidrug-resistant Tuberculosis

Multidrug-resistant tuberculosis (MDR-TB), defined as TB that is resistant to at least isoniazid (INH) and rifampicin (RIF). Treatment of MDR isolates requires the use of more costly and more toxic second-line drugs. Inappropriate treatment can result in the development of resistance to additional antibiotics and increase mortality. The detection of rifampicin resistance serves as surrogate marker for detecting MDR-TB.