Non-pathogenic Mycobacterium Smegmatis

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Non-pathogenic Mycobacterium Smegmatis

Mycobacterium leprae is a pathogenic bacteria that causes leprosy, a disease which affects mainly the skin, peripherical nerves, eyes and mucosa of the upper respiratory tract. Its highly reduced genome makes it an interesting species as a model for reductive evolution within the mycobacterial genus; it shares the same ancestor with Mycobacterium tuberculosis (MTB). A functional network for MTB was generated previously and extensive computational analyses were conducted to reveal the biological organization of the organism on the basis of the network’s topological properties. Here, we use genomic sequences and functional data from public databases to build protein functional networks for another slow grower, Mycobacterium leprae (MLP) and the fast growing non-pathogenic Mycobacterium smegmatis (MSM). Together with the MTB network, this provides an opportunity for comparison of three mycobacteria with different sized genomes. In this paper, we use network centrality measures to systematically compare MTB, MLP and MSM to quantify differences between these organisms at the systems biology level and to study network biology and evolution.
  • Share this page
  • Facebook
  • Twitter
  • LinkedIn
  • Google+
  • Pinterest
  • Blogger

Last date updated on January, 2021