|Diabetes mellitus (DM) TB co-infection is associated with poor glycemic control in DM patients. Reactive hyperglycemia often accompanies chronic infections due to the associated proinflammatory state and release of counter-regulatory stress hormones such as epinephrine, cortisol and glucagon, all insulin antagonists. Tuberculosis (TB) remains a major source of morbidity and mortality throughout the world; one-third of the worldâs population is estimated to be infected with Mycobacterium tuberculosis (MTB), whereby approximately nine million people develop the disease each year, and almost two million die annually as a result. Epidemiological analyses have elucidated an association between DM and the development of TB. Diabetes mellitus (DM) is the most frequent chronic endocrine disorder; it is a non-transmissible pathological entity, characterized by disorders of the entire metabolism but particularly, of carbohydrate metabolism.