To date, various nanodrug systems have been developed for different routes of administration, which include dendrimers, nanocrystals, emulsions, liposomes, solid lipid nanoparticles, micelles, and polymeric nanoparticles. Nanodrug systems have been employed to improve the efficacy, safety, physicochemical properties, and pharmacokinetic/pharmacodynamic profile of pharmaceutical substances. In particular, functionalized nanodrug systems can offer enhanced bioavailability of orally taken drugs, prolonged half-life of injected drugs (by reducing immunogenicity), and targeted delivery to specific tissues. Thus, nanodrug systems might lower the frequency of administration while providing maximized pharmacological effects and minimized systemic side effects, possibly leading to better therapeutic compliance and clinical outcomes. In spite of these attractive pharmacokinetic advantages, recent attention has been drawn to the toxic potential of nanodrugs since they often exhibit in vitro and in vivo cytotoxicity, oxidative stress, inflammation, and genotoxicity. A better understanding of the pharmacokinetic and safety characteristics of nanodrugs and the limitations of each delivery option is necessary for the further development of efficacious nanodrugs with high therapeutic potential and a wide safety margin.
Journal impact factor is an index or a criteria devised by Eugene Garfield to categorize journals based on their citations. Impact factor is considered as a putative marker to indicate the journal quality. But the recent policies being adopted to improve the impact factor is becoming a topic of controversies today. This current scenario questions the reliability of impact factor. The citation index cannot be considered to determine the scientific quality of an article because the technicalities are not considering the scientific quality. Knowing or reading an article is not enough to determine their quality validating the content and approving the findings and revalidating the facts is vital in scientific research. It is highly impossible to do a scholar check in each and every article to detect fraudulent or unsubstantial citations.
Last date updated on September, 2014