|To date, various nanodrug systems have been developed for different routes of administration, which include dendrimers, nanocrystals, emulsions, liposomes, solid lipid nanoparticles, micelles, and polymeric nanoparticles. Nanodrug systems have been employed to improve the efficacy, safety, physicochemical properties, and pharmacokinetic/pharmacodynamic profile of pharmaceutical substances. In particular, functionalized nanodrug systems can offer enhanced bioavailability of orally taken drugs, prolonged half-life of injected drugs (by reducing immunogenicity), and targeted delivery to specific tissues. Thus, nanodrug systems might lower the frequency of administration while providing maximized pharmacological effects and minimized systemic side effects, possibly leading to better therapeutic compliance and clinical outcomes. In spite of these attractive pharmacokinetic advantages, recent attention has been drawn to the toxic potential of nanodrugs since they often exhibit in vitro and in vivo cytotoxicity, oxidative stress, inflammation, and genotoxicity. A better understanding of the pharmacokinetic and safety characteristics of nanodrugs and the limitations of each delivery option is necessary for the further development of efficacious nanodrugs with high therapeutic potential and a wide safety margin.
Open Access journals make a quick review of articles and inform the authors within twenty one days of submission with the help of 3000 editorial team and quality review board which is ready to offer useful and informative results. Most of the peer-reviewed open access journals of OMICS Group is indexed in well-known indexing services like PubMed, Scopus, AGORA, ISI, ProQuest, Gale, Chemical Abstracts, and HINARI etc. Articles published in OMICS Group journals are permanently archived in the respective peer reviewed journals thus providing immediate and permanent access to individual papers and application of the scientific information. So, it is providing chance to get attract more number of students towards scientific research.