To date, various nanodrug systems have been developed for different routes of administration, which include dendrimers, nanocrystals, emulsions, liposomes, solid lipid nanoparticles, micelles, and polymeric nanoparticles. Nanodrug systems have been employed to improve the efficacy, safety, physicochemical properties, and pharmacokinetic/pharmacodynamic profile of pharmaceutical substances. In particular, functionalized nanodrug systems can offer enhanced bioavailability of orally taken drugs, prolonged half-life of injected drugs (by reducing immunogenicity), and targeted delivery to specific tissues. Thus, nanodrug systems might lower the frequency of administration while providing maximized pharmacological effects and minimized systemic side effects, possibly leading to better therapeutic compliance and clinical outcomes. In spite of these attractive pharmacokinetic advantages, recent attention has been drawn to the toxic potential of nanodrugs since they often exhibit in vitro and in vivo cytotoxicity, oxidative stress, inflammation, and genotoxicity. A better understanding of the pharmacokinetic and safety characteristics of nanodrugs and the limitations of each delivery option is necessary for the further development of efficacious nanodrugs with high therapeutic potential and a wide safety margin.
Open Access should be seen as a means of accelerating scientific discovery by providing free and unrestricted access of scientific knowledge via the Internet. An essential role of Open Access is the long-term preservation of peer-reviewed scholarly journal articles and research data. An Open Access publishing group focuses on to encourage innovation, socio-economic development, and flow of knowledge around the world. One such, Open Access is OMICS which is committed ultimately for public welfare to stimulate the growth of global science, as well as maintain the quality of scientific achievements at the same time. Bio crimes related articles are published in rice research open access journal, this journal publishes quality manuscripts which has good impact on the society.
Last date updated on September, 2014