|To date, various nanodrug systems have been developed for different routes of administration, which include dendrimers, nanocrystals, emulsions, liposomes, solid lipid nanoparticles, micelles, and polymeric nanoparticles. Nanodrug systems have been employed to improve the efficacy, safety, physicochemical properties, and pharmacokinetic/pharmacodynamic profile of pharmaceutical substances. In particular, functionalized nanodrug systems can offer enhanced bioavailability of orally taken drugs, prolonged half-life of injected drugs (by reducing immunogenicity), and targeted delivery to specific tissues. Thus, nanodrug systems might lower the frequency of administration while providing maximized pharmacological effects and minimized systemic side effects, possibly leading to better therapeutic compliance and clinical outcomes. In spite of these attractive pharmacokinetic advantages, recent attention has been drawn to the toxic potential of nanodrugs since they often exhibit in vitro and in vivo cytotoxicity, oxidative stress, inflammation, and genotoxicity. A better understanding of the pharmacokinetic and safety characteristics of nanodrugs and the limitations of each delivery option is necessary for the further development of efficacious nanodrugs with high therapeutic potential and a wide safety margin.
Journals are the means of disseminating research findings. They help the common man to explore the discovery made by scholars. Journals play a very important role in maintaining periodical record of events and help us in collecting information and thus streamlining our knowledge. Generally, journals refer to collection of Scholarly articles that are published regularly and are peer reviewed. As its peer reviewed it enhances the collaborative efforts from scholars. Internationally published journals accelerate scientific research by increasing quality, competency and credibility. They increase the performance of each and every scholar there by contributing a lot to scientific community.