Nanodrug delivery have been designed to overcome these challenges due to the development and fabrication of nanostructures. It has been reported that, nanostructures have the ability to protect drugs from the degradation in the gastrointestinal tract, the technology also allows target delivery of drugs to various areas of the body. The technology enables the delivery of drugs that are poorly water soluble and can provide means of bypassing the liver, thereby preventing the first pass metabolism. Nanotechnology increases oral bioavailability of drugs due to their specialized uptake mechanisms such as absorptive endocytosis and are able to remain in the blood circulation for a longer time, releasing the incorporated drug in a controlled fashion leading to less plasma fluctuations and minimizing side-effects.
Open Access articles are immediately, freely available on their Web site, a model mostly funded by charges paid by the author (usually through a research grant). The alternative for a researcher is self-archiving (i.e., to publish in a traditional journal, where only subscribers have immediate access, but to make the article available on their personal and/or institutional Web sites (including so-called repositories or archives)), which is a practice allowed by many scholarly journals.
Last date updated on September, 2014