The preparation of nanoparticles via emulsion based techniques requires the use of compounds to stabilize the formulation. Poly(vinyl alcohol)(PVA) and human serum albumin (HSA) have been used effectively as stabilizers in Doxorubicin-loaded PLGA nanoparticles. Nanoparticle size appears to decrease with increases in stabilizer concentration between 0.5 and 5% w/v.it is important to note that high nanoparticle recovery is required for reducing manufacturing costs. High entrapment efficiency will reduce the amount of carrier needed for the administration to the target site and help eliminate wastage during manufacturing.Beyond inhibiting tumor growth, combination nanoparticle drugs will allow better dosage optimization and convenience.Nanoparticles co-loaded with Doxorubicin and Paclitaxel in a concentration ratio of 2:1 showed high anti-tumor activity against three different types of tumor cells. Again, these co-loaded nanoparticles were found to be superior to single drug formulations. (Al-Achi A, Jonathan Lawrence BS,Micelles: Chemotherapeutic Drug Delivery)
Academic journals are periodicals in which researchers publish their findings, mostly the recent ones. Academic journals are typically peer-reviewed journals that publish theoretical discussions and articles that critically review already published work. Academic journals serve as an important forum for researchers and academicians from where they can access important information about recent developments in their field. These journals are the first choice for any in-depth examination of an issue related to science. Science as we know is scarcely imaginable without the academic journal. OMICS Group International Journals fall under the academic category as they strictly adhere to peer-review process and follow the format by publishing mostly the original work.
Last date updated on July, 2014