Gold nanoparticles are allowed to be used in biological and medical application owing to their good biocompatibility as well as excellent optical and electronic properties. In recent years, Au nanomaterials have attracted greater attention from researchers because it was demonstrated that Au nanomaterials have great potential for cancer photothermal therapy.A novel anticancer drug can be designed, which is Au nanoparticleliposome hybrids delivery system. The delivery system allows deep tissue detection, therapy, and monitoring on living body, and the hybrids can be designed by controlling the thickness of the gold shell and the diameter of the core, which realizes that the surface plasmon resonance and the optical absorption of gold nanoshells can be tuned to the NIR to enhance spectral signal in the cytoplasm and obtain the detection signal. Therefore, the advantages of gold particle-liposome hybrids are as follows: (1) biodistribution can be controlled by the change of the nanoparticle properties,preservation an effective blood concentration by escaping the removal carried out by the reticuloendothelial system,high potency hydrophobic compounds can be dispersed in water and delivered systemically by nanoparticles,nanoparticles can enhance the level of signal detection for the more sensitive detection of disease. (DaweiGao,Drug Design for Cancer: Gold Nanoparticle-Liposome Hybrids for Drug Delivery and Monitoring)
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Last date updated on July, 2014