alexa Medical Journals In Nanoparticles|OMICS International|Translational Medicine

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Medical Journals In Nanoparticles

Micelles have become one of the main players in nanoparticle research. Although micelles have been around for decades, it was not until recently that these particles were finally utilized in advanced drug delivery systems.Collagenases also help induce vascular permeability by causing disintegration of matrix tissue surrounding blood vessels. Fenestrations in regular vessels are too small for penetration of nanoparticles, compared to those as large as 600-800 nm in tumor tissue.Therefore, polymeric micelles are able to penetrate tumor tissue selectively, achieve higher concentrations, and have a longer duration of action than regular dosage forms, subsequently requiring less dosing. Regular body processes also play a role in drug permeability and retention.CMC values for nanoparticles are generally much lower than most commercially available products (on the order of 10-6or 10-7); if the micelles faced dilution, (i.e., injection into the body) then a drop in concentration below the CMC would cause loss of structural integrity.Encapsulation of hydrophilic drugs has been attempted, but currently has been unsuccessful and needs to be studied further. The entire complex of micelle and drug can then vary in size from ten to hundreds of nanometers; although, nanoparticles under 100 nm seem to fair the best in vivo. There are several popular methods of nanoparticle synthesis which will be highlighted: emulsificationsolvent evaporation, solvent displacement, and salting out. (Al-Achi A, Jonathan Lawrence BS,Micelles: Chemotherapeutic Drug Delivery) Medical Journals provide a platform for outstanding research around the globe in the field of medicine. These scholarly journals aim to contribute to the progress and application of scientific discoveries, by providing free access to the research information. The published work reaches the general public and the scientific community immediately after publication, thus providing higher citation rates for the author. Medical Journals are supported by 5000 internationally renowned editorial board members and a high quality review board. Medical Journals use online Editorial Manager System for quick and high quality review process. Articles of Medical journals are subjected to peer reviewing and these are included in the standard indexing databases like ISI, Scopus, EBSCO, CAS, HINARI etc. All the articles published in Medical journals are permanently archived in respective peer reviewed journals thus providing unrestricted utilization and requisition of the scientific information.
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Last date updated on July, 2014