Micelles have become one of the main players in nanoparticle research. Although micelles have been around for decades, it was not until recently that these particles were finally utilized in advanced drug delivery systems.Collagenases also help induce vascular permeability by causing disintegration of matrix tissue surrounding blood vessels. Fenestrations in regular vessels are too small for penetration of nanoparticles, compared to those as large as 600-800 nm in tumor tissue.Therefore, polymeric micelles are able to penetrate tumor tissue selectively, achieve higher concentrations, and have a longer duration of action than regular dosage forms, subsequently requiring less dosing. Regular body processes also play a role in drug permeability and retention.CMC values for nanoparticles are generally much lower than most commercially available products (on the order of 10-6or 10-7); if the micelles faced dilution, (i.e., injection into the body) then a drop in concentration below the CMC would cause loss of structural integrity.Encapsulation of hydrophilic drugs has been attempted, but currently has been unsuccessful and needs to be studied further. The entire complex of micelle and drug can then vary in size from ten to hundreds of nanometers; although, nanoparticles under 100 nm seem to fair the best in vivo. There are several popular methods of nanoparticle synthesis which will be highlighted: emulsificationsolvent evaporation, solvent displacement, and salting out. (Al-Achi A, Jonathan Lawrence BS,Micelles: Chemotherapeutic Drug Delivery)
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Last date updated on July, 2014