Encapsulation of biologics in biodegradable polymeric nanoparticles may be an ideal strategy. Biodegradable polymers, such as poly (lactic-co-glycolic acid) (PLGA), poly (lactic acid) (PLA), poly (glycolic acid) (PGA), polyethylene glycol (PEG) and poly (caprolactone) (PCL), are widely studied for the preparation of nanoparticles. PLGA copolymer based system produces high molar mass of lactic and glycolic acids. Studies with PLGA suggest that acidic pH in the core of nanoparticles significantly induces protein aggregation, and reduces biological activity of therapeutic proteins.
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Last date updated on July, 2014