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pH nanosensors containing pH indicator and reference fluorophores conjugated to nanoparticles through covalent bonds. Covalent attachment prevents the fluorophores from leaching from the particles. However, these sensors have some disadvantages, of which the predominant one is that the sensors can only measure pH in a narrow range from 5.5 to 7.5, whereas endosomes (approximately pH 5~6) and lysosomes (approximately pH 4~5) have more acidic environments, making these pH sensors inappropriate for pH measurements in these acidic cellular compartments. Another disadvantage of these sensors is a diminished cellular uptake, which is due to the present of anionic surfactant dioctylsulfosuccinate (AOT) used for the reverse polymerization.
Title:A New Folate Targeting Ph Nanosensor with an Extended Measuring Range
Link:Sun H, Windschiegl B, Andersen TL, Rasmussen TE, Olsen LF, et al. (2014) A New Folate Targeting Ph Nanosensor with an Extended Measuring Range. J Nanomed Nanotechnol 5: 188.
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Last date updated on June, 2014