"In coagulation factors, of the proteins annotated to the GO term negative regulation of blood coagulation, annexin A2, apolipoprotein E, and plasminogen there was ambiguous regulation in relation to the preeclamptic state since they were identified as upregulated or down regulated different studies. We speculate that this could be due to heterogeneity in sample sources or maternal response the pathology. Plasminogen is primarily synthesized in the liver and is cleaved into plasmin at the site of insult by tissue or urokinase plasminogen activators in the early steps of fibrinolysis to the active protease plasmin. Annexin 2 also acts in the fibrinolysis pathway.
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Citation: Wong F, Cox B (2014) Proteomics Analysis of Preeclampsia, a systematic Review of Maternal and Fetal Compartments. J Proteomics BioinformS10: 001."
Last date updated on July, 2014