Neuroleptic is the condition of depressing nerve functions with reduces nervous tension with the usage of drugs. This would pertain with various drugs used in the treatment of psychosis. It is a state of limited range of emotion, lack of initiative and apathy. Malignant neuroleptic syndrome is the life-threatening idiosyncratic reaction caused with these neuroleptic drugs. Symptoms of Malignant neuroleptic syndrome followed with fever, muscular rigidity, altered mental status and autonomic dysfunction. Haloperidol and fluphenazine, other drugs are the neuroleptics changes in drug regimen to antagonize central dopamine D2 receptors may occasionally cause malignant neuroleptic syndrome. Following are the factors for developing neuroleptic malignant syndrome, use of high levels of depot preparations, use of neuroleptic drugs, withdrawal of anti-parkinsonian medications, and use of other agents with central D2 receptor antagonist activity like anticholinergic drugs promethazine, prochlorperazine, and amoxapine. Following are the complication of neuroleptics cardiac arrest, rhabdomyolysis, renal failure, seizures, respiratory failure, disseminated intravascular coagulation, aspiration pneumonitis, and deterioration in psychiatric condition due to drug withdrawal, infection, hepatic failure, pulmonary embolism.
Last date updated on June, 2014