The main obstruction is that the genetic materials are highly sensitive cannot be formulated in traditional pharmaceutical ways, because it becomes degraded within the organism and cannot perform its function and leads to lethality, to overcome viral vectors are generally employed to deliver the therapeutic gene to the cells in which it has to act and desired protein is expressed. Sometimes these viral vectors may revert and also leads to tumours hence researchers are preferring non viral vectors which doesnt show biological alterations and also poses ideal characters of therapeutic gene transfer. This made to evolve lipid nano particles which carry desired gene with its own biological way.
Lipid Nanoparticles have been successfully applied in treating ocular degeneration where ocular delivery of therapeutic gene has been done. Another supreme application of this technology is in formulation of drugs which are not soluble or which are much difficult to absorb into in to the body by natural means. The researchers are trying to increase effectiveness of this technology by all means combining these three skills Pharmacokinetics, Nanotechnology and Gene Therapy.
The impact factor of journal provides quantitative assessment tool for grading, evaluating, sorting and comparing journals of similar kind. It reflects the average number of citations to recent articles published in science and social science journals in a particular year or period, and is frequently used as a proxy for the relative importance of a journal within its field. It is first devised by Eugene Garfield, the founder of the Institute for Scientific Information. The impact factor of a journal is evaluated by dividing the number of current year citations to the source items published in that journal during the previous two years.