Nisoldipine is a second generation of dihydropyridine calcium antagonist which has a selective arteriolar vasodilatation but shows negligible effects on the other vessels and myocardium. Nisoldipine is a yellow crystalline substance,practically insoluble in water but soluble in methanol. It has a molecular weight of 388.4 g/mol. It is used alone or together with other medicines to treat high blood pressure. Nisoldipine is available as extended release tablets. Many analytical chemical investigations have been published for the determination of Nisoldipine, including the determination in formulations by voltammetry , polarography and HPLC. Since Nisoldipine has light sensitivity, its stability, kinetics of degradation and determination of impurities are reported by various techniques including UV, polarography and HPLC. Therefore, the purpose of this investigation was to develop and validate a method using a simple, rapid, sensitive, precise, accurate and specific reversed phase HPLC-DAD assay. The method uses a simple mobile phase composition and the rapid run time of less than 10 min.
Last date updated on April, 2024
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