|Nonsteroidal anti-inflammatory drugs (NSAIDs), including lowdose aspirin, are among the most widely prescribed medications, with approximately 30 million patients worldwide ingesting NSAID . NSAID could cause small intestinal injury. It became clear from the studies of post-mortem samplesby Bjarnason and colleagues (1993) that NSAID use is alsoassociated with significant damage to the more distal regionsof the small intestine (i.e. distal to the ligament of Treitz) . Small intestinal injury includes bleeding, erosion, and ulceration . Serious complications can includemassive bleeding, perforation and strictures, sometimes leading to death . PubMed with key words âNSAID and enteropathyâ was used in 1994 through 2013 for selecting articles. The aim of this short review is to summarize out current understanding of NSAID induced small intestinal injury.
NSAID can affect the jejunum and ileum . Capsule endoscopy (CE) and double-balloon endoscopy (DBE) are diagnostic methods for visualizing small intestinal lesions]. In the DBE group, out of 61 patients, ulcers or erosions were observed in the ileum in six patients and in the jejunum in one patient, respectively . In the cases indicated for enteroscopy, NSAIDs enteropathy occurred in half of the patients taking NSAIDs .
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