Nuclear Localization Signal|omicsgroup|Journal Of Biotechnology And Biomaterials

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Nuclear Localization Signal

APE1 is a central enzyme of BER-pathway with primary two major independent cellular functions; repair and redox. Both functions are displayed by two different regions of the protein. Primarily, repair function through C-terminus, which involves removal of AP sites in DNA. Second function is reductive activation of several TFs displayed via disordered N-terminus which also possesses the Nuclear Localization Signal (NLS), controlling gene expression for significant cellular pathways. Because of redox activity, APE1 is also known as redox effector factor-1. OMICS Group International is one of the leading Open Access Publishers which is publishing 700+ peer-reviewed journals with the support of 50,000+ editorial board members as editorial team and aimed to disseminate the scholarly knowledge to the scientific society.
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Last date updated on April, 2021