APE1 is a central enzyme of BER-pathway with primary two major independent cellular functions; repair and redox. Both functions are displayed by two different regions of the protein. Primarily, repair function through C-terminus, which involves removal of AP sites in DNA. Second function is reductive activation of several TFs displayed via disordered N-terminus which also possesses the Nuclear Localization Signal (NLS), controlling gene expression for significant cellular pathways. Because of redox activity, APE1 is also known as redox effector factor-1.
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Last date updated on July, 2014