Obesity in adulthood is characterized by adipocyte hypertrophy. Adipose tissue participates in the regulation of energy homeostasis. High-fat diet-induced insulin resistance associated with obesity is a major risk factor for diabetes and cardiovascular disease. Adipose tissue itself serves as the site of triglyceride (TG) storage and free fatty acid release in response to changing energy demands. Adipose tissue also participates in the regulation of energy homeostasis as an important endocrine organ that secretes a number of biologically active adipokines such as adipsin, leptin, plasminogen activator inhibitor-1 , resistin , TNF-Î± , and adiponectin . LPL is one such adipokine
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Last date updated on November, 2021