|Osteoarthritis (OA) is the utmost common arthropathy in the worldwide, which is considered by the deprivation of articular cartilage and affects all joint structures such as the subchondral bone, fibrocartilage, ligament, capsule, and synovium. The knee OA is highly dominant in individuals of both sexes over 50 years old, and the great levels of pain lead the loss of functional capacity and quality of life.
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