|Bone is a living tissue that undergoes continuous remodeling, a process which depends on bone resorption by osteoclasts on the one hand and bone formation by osteoblasts on the other. These mechanisms are tightly coupled in space and time. Measurements of specific, circulating markers of bone resorption and formation, respectively released by osteoclasts and osteoblasts, reflect the overall timing of bone turnover and help defining the balance between these competing constituents of bone metabolism.
A journal is a periodical publication intended to further progress of science, usually by reporting new research. Most journals are highly specialized, although some of the oldest journals publish articles, reviews, editorials, short communications, letters, and scientific papers across a wide range of scientific fields. Journals contain articles that peer reviewed, in an attempt to ensure that articles meet the journal's standards of quality, and scientific validity. Each such journal article becomes part of the permanent scientific record.