|Bone is a living tissue that undergoes continuous remodeling, a process which depends on bone resorption by osteoclasts on the one hand and bone formation by osteoblasts on the other. These mechanisms are tightly coupled in space and time. Measurements of specific, circulating markers of bone resorption and formation, respectively released by osteoclasts and osteoblasts, reflect the overall timing of bone turnover and help defining the balance between these competing constituents of bone metabolism.
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