Tau is an outstanding biochemical marker of neurofibrillary degeneration (NFD), well correlated with clinical manifestations. Tau pathology concerns many familial or sporadic neurodegenerative disorders, such as Alzheimer's disease (AD), progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), Pick's disease (PiD), FTDP-17, myotonic dystrophy (MyoD), and many other diseases. Tau pathology is suspected to accumulate first in the Lateral Entorhinal Cortex (LEC) and then spread to other sites in the medial temporal lobe, such as the perirhinal cortex, as well as neocortical sites such as the posterior cingulate cortex.
Scientific journal is a periodical publication intended to further progress of science, usually by reporting novel research. There are thousands of scientific journals in publication, and many more have been published at various points in the past. Most journals are highly specialized, although some of the oldest journals publish articles and scientific papers across a wide range of scientific fields. Scientific journals contain articles that are peer reviewed, to ensure that articles meet the journal's standards of quality, and scientific validity. The publication of the results of research is an essential part of the scientific method. If they are describing experiments or calculations, they must supply enough details that an independent researcher could repeat the experiment or calculation to verify the results. Each such journal article becomes part of the permanent scientific record.
Last date updated on September, 2014