|Tau is an outstanding biochemical marker of neurofibrillary degeneration (NFD), well correlated with clinical manifestations. Tau pathology concerns many familial or sporadic neurodegenerative disorders, such as Alzheimer's disease (AD), progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), Pick's disease (PiD), FTDP-17, myotonic dystrophy (MyoD), and many other diseases. Tau pathology is suspected to accumulate first in the Lateral Entorhinal Cortex (LEC) and then spread to other sites in the medial temporal lobe, such as the perirhinal cortex, as well as neocortical sites such as the posterior cingulate cortex.
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