alexa A Fibrosarcomatous ("High-Grade") Variant of Dermatofibrosarcoma Protuberans (DFSP | OMICS International | Abstract
ISSN: 2157-2518

Journal of Carcinogenesis & Mutagenesis
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Case Report

A Fibrosarcomatous ("High-Grade") Variant of Dermatofibrosarcoma Protuberans (DFSP

Wafi Attaallah*, Kemal Turkoz and Cumhur Yegen

Department of General Surgery, Marmara University Pendik Teaching and Research Hospital, Istanbul, Turkey

Corresponding Author:
Wafi Attaallah, MD
Department of General Surgery Marmara University Pendik Teaching and Research Hospital
Fevzi Cakmak mah. Mimar Sinan cad. 41
Ustkaynarca, Pendik, Istanbul, 34899 Turkey
Tel: +90 216 657 06 06
Fax: +90 216 657 06 95
E-mail: [email protected]

Received May 15, 2014; Accepted June 21, 2014; Published June 25, 2014

Citation: Attaallah W, Turkoz K, Yegen C (2014) A Fibrosarcomatous ("High-Grade") Variant of Dermatofibrosarcoma Protuberans (DFSP). J Carcinog Mutagen S4:007. doi: 10.4172/2157-2518.S4-007

Copyright: © 2014 Attaallah W, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Dermatofibrosarcoma protuberans (DFSP) is a relatively uncommon soft tissue tumor with intermediate-to-low grade malignancy. There is usually little nuclear pleomorfism and only low to moderate mitotic activity. Conventional DFSP, usually have fewer than 5 mitotic figures/10 high-power fields. We describe a case of a 74- year old male patient who presented to the surgical clinic with active bleeding from a painless mass in his right arm which has grown progressively over a period of two years. Local excision of the mass was performed. Histopathological evaluation showed dermatofibrosarcoma protuberans with high mitotic activity (15 mitotic figures/10 high-power fields and high nuclear pleomorphism. Therefore, it was diagnosed as a fibrosarcomatous (high grade) variant of dermatofibrosarcoma protuberans (FS-DFSP). Only 225 cases of DFSP-FS being described in the literature, thus, the importance of this case report arises due to the rarity of this clinical and histopathologic entity.


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