alexa Antidiarrhoeal Effects of Ethanolic Extract of Unripe fruit of Aegle Marmelos (Bael) in Mice
e-ISSN: 2322-0139 p-ISSN: 2322-0120

Research & Reviews: Journal of Pharmacology and Toxicological Studies
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Research Article

Antidiarrhoeal Effects of Ethanolic Extract of Unripe fruit of Aegle Marmelos (Bael) in Mice

Manjunath V Jali*, Nirmala P1, Annamalai AR1, and Basavaraj KM2

1Department of Pharmacology, TVM College of Pharmacy, Bellary, Karnataka. India.

2Department of Pharmacology, R. M. Medical College, Annamalainagar, Tamilnadu, India.

3Department of Chemistry Vijayanagar Sri Krishndevaraya University Bellary, Karnataka, India.

*Corresponding Author:
Manjunath V Jali
TVM College of Pharmacy, YN Shastrinagar, Kappagal Road, Bellary-583103, Karnataka. India
Phone: +91 9448488226
Fax: +91 8392257945

Received date: 13 January 2014 Accepted date: 15 March 2014

 

Abstract

This present study was undertaken to investigate antidiarrhoeal activity of ethanolic extract of unripe fruit of Aegle marmelos (EEAM) in castor oil, prostaglandin E2 (PGE2), 5-Hydroxytryptamine (5-HT), and carbachol induced diarrhoea in mice. The higher dose of EEAM (800mg/kg) completely prevented the diarrhoea whereas the lower doses (200 and 400mg/kg) significantly increased the time of induction of diarrhea, decreased the number and weight of wet faeces in castor oil induced diarrhoea. The higher doses of EEAM (400 and 800 mg/kg) significantly increased time of induction of diarrhoea, decreased the number and weight of wet faeces in PGE2, 5-HT and carbachol induced diarrhoea, whereas lower doses had no effect on these parameters.

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