Antidiarrhoeal Effects of Ethanolic Extract of Unripe fruit of Aegle Marmelos (Bael) in Mice
- *Corresponding Author:
- Manjunath V Jali
TVM College of Pharmacy, YN Shastrinagar, Kappagal Road, Bellary-583103, Karnataka. India
Phone: +91 9448488226
Fax: +91 8392257945
Received date: 13 January 2014 Accepted date: 15 March 2014
This present study was undertaken to investigate antidiarrhoeal activity of ethanolic extract of unripe fruit of Aegle marmelos (EEAM) in castor oil, prostaglandin E2 (PGE2), 5-Hydroxytryptamine (5-HT), and carbachol induced diarrhoea in mice. The higher dose of EEAM (800mg/kg) completely prevented the diarrhoea whereas the lower doses (200 and 400mg/kg) significantly increased the time of induction of diarrhea, decreased the number and weight of wet faeces in castor oil induced diarrhoea. The higher doses of EEAM (400 and 800 mg/kg) significantly increased time of induction of diarrhoea, decreased the number and weight of wet faeces in PGE2, 5-HT and carbachol induced diarrhoea, whereas lower doses had no effect on these parameters.