alexa Aurora Kinase Inhibitors in Target Specific Cancer Treatment
e-ISSN:2320-1215 p-ISSN: 2322-0112

Research & Reviews in Pharmacy and Pharmaceutical Sciences
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Commentary

Aurora Kinase Inhibitors in Target Specific Cancer Treatment

Yusuf Tutar*

Department of Pharmaceutical Basic Sciences, Faculty of Pharmacy, Division Of Biochemistry, Cumhuriyet University, Sivas, Turkey

*Corresponding Author:
Yusuf Tutar, Cumhuriyet University, Faculty of Pharmacy, Department of Pharmaceutical Basic Sciences, Division of Biochemistry, Sivas 58140, Turkey
Tel: +90 346 219 1010
Fax: +90 346 219 1634
E-mail: [email protected]

Received date: 06/02/2016 Accepted date: 17/02/2016 Published date: 22/02/2016

 

 

Abstract

Targeted therapy is one of the major treatment modalities in medical oncology. Targeted therapy aims to inhibit oncogenic pathways by interfering with target biomolecules. For this reason drug designers have focused on investigation of new targets in order to develop efficient cancer drugs [1]. Aurora kinases are important members of the serine/threonine kinases and three forms of the Aurora kinases have been identified: Aurora-A, Aurora-B, and Aurora-C in human. Especially, Aurora-A and Aurora-B play key roles in mitotic checkpoint activation, chromosome orientation, cell proliferation, cytokinesis, and mitotic spindle formation in cells. Alteration of their expression level is related with mitotic errors and aberrant expression of these enzymes may trigger multiple oncogenic pathways. Therefore, Aurora-A and Aurora-B kinases have been potential targets in new generation cancer drug development research.

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