alexa BMP4 Gene and Pathophysiology of Cleft Lip and Palate.
e-ISSN: 2320-7949 and p-ISSN: 2322-0090

Research & Reviews: Journal of Dental Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Short Communication

BMP4 Gene and Pathophysiology of Cleft Lip and Palate.

Savitha Sathyaprasad*, Sharma SM, and Veena Shetty.

A B Shetty Institute of Dental Sciences, Mangalore, Karnataka, India.

*Corresponding Author:
Savitha Sathyaprasad
A B Shetty Institute of Dental Sciences, Mangalore, Karnataka, India

Received: 6 February 2014 Revised: 24/02/2014 Accepted:14March 2015



The rapid proliferative expansion and complex morphogenetic events that coordinate the development of face underpin the sensitivity of the structure to genetic and environmental insult and provide an explanation for the high incidence of midfacial malformation. Most notable of these malformations is cleft lip with or without palate. Despite the global impact of the disorder and some recent progress in identifying the causative genes for the non - syndromic forms of CLP, our knowledge on the key genetic factors and the environmental mutants therein contributing to CLP remains still remarkably patchy. The current understanding of the molecular and cellular processes that orchestrate morphogenesis of the midface, with emphasis on events leading to the fusion of the lip and primary palate is detailed in this review. The role of the candidate gene BMP4 in nsCLP, identified from relevant animal model systems and the likely events perturbed by the key gene pin pointed in human studies are discussed in this light. In this present review the normal craniofacial patterning and morphogenesis of lip and palate are discussed with a focus on the role of BMP signaling therein.


Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version