alexa Colony Forming Unites - Endothelial Progenitor Cells (C

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Research Article

Colony Forming Unites - Endothelial Progenitor Cells (CFU-EPCs) A surrogate marker for diabetic retinopathy and high cardiovascular mortality rate

Arnon Blum1*, Dorina Socea2, Nina Pastukh3, Hanin Jabaly2

1Department of Medicine, Baruch Padeh Poria Medical Center, Faculty of medicine in the Galilee Bar Ilan University, Israel.

2Department of Ophthalmology, Baruch Padeh Poria Medical Center, Faculty of medicine in the Galilee Bar Ilan University, Israel.

3Vascular Biology Research Laboratory, Baruch Padeh Medical Center, Faculty of medicine in the Galilee Bar Ilan University, Israel.

*Corresponding Author:
Arnon Blum
Department of Medicine, Baruch Padeh Poria Medical Center, Faculty of medicine in the Galilee, Bar Ilan University, Lower Galilee 15208, Israel.
E-mail: [email protected]; [email protected]

Received date: 10 Apr 2016; Revised date: 27 May 2016; Accepted date: 30 May 2016



Purpose: Diabetic retinopathy is a risk factor for increased cardiovascular death. Our purpose was to find a significant difference in levels of endothelial progenitor cells (EPCs) in the peripheral blood of patients at different stages of diabetic retinopathy. Design: A prospective study. Colony forming units of endothelial progenitor cells (CFU-EPCs) in peripheral blood were counted. 40 subjects were enrolled (10 healthy [41±8 y], 10 type 2 diabetes mellitus (T2DM) [64±12 y] without retinopathy, 10 T2DM patients [62±26 y] with non-proliferative retinopathy (NPDR), 10 T2DM patients [66±9 y] with proliferative retinopathy (PDR)). The study was approevd by the ethics committee of the hospital and every subject signed a soncent form before enrollment. Methods: Growing CFU-EPCs was by the Hill's EPCs protocol. Blood was drawn early in the morning and was processed within 1 hour. Mononuclear cells were separated and cultured on fibronectin-coated plates with EndoCult medium (StemCell technologies, Vancouver BC Canada) for 5 days. CFU-EPCs were counted on day 5 (an average of 8 wells). Results: Healthy subjects had 36±8 CFU-EPCs, patients without retinopathy had 13±12 CFU-EPCs (p<0.01), patients with NPDR 22±26 CFU-EPCs (p=NS), and 2±2 CFU-EPCs in patients with PDR (p<0.01). A significant difference was found between patients with PDR and with NPDR (p<0.05). Conclusions: CFU-EPCs are inhibited in T2DM patients with DPR. Levels of CFU-EPCs may be used as a surrogate biologic marker for severity of diabetic retinopathy and for cumulative vascular risk.


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