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Research Article

Comparative Study on the Effect of Various Superdisintegrants in the Formulation of Ibuprofen Fast Dissolving Tablets

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In the present study, an attempt has been made to formulate fast dissolving tablets of Ibuprofen. Tablets were prepared using a direct compression method employing superdisintegrants such as Kyron T-314, sodium starch glycolate (Explotab), croscarmellose sodium (Ac‐Di‐Sol), and crospovidone. The prepared tablets were evaluated for their physiochemical properties like wetting time, water absorption ratio, dispersion time, disintegration time and in vitro drug release studies. It was observed that the results obtained from formulations containing the Kyron T-314 and CP as superdisintegrants showed a better profile in comparison to CCS and SSG. The hardness of the tablets was in the range of 3.0 ‐ 4.0 Kg/cm². The percent weight variation of the tablets was below the range. Weight variation test results showed that the tablets were deviating from the average weight within the permissible limits of ±7. 5 %. Drug content uniformity study results showed the uniform dispersion of the drug throughout the formulation, i.e. 97.24% to 99.98%. Tablets of ibuprofen prepared using cross povidone (CP) exhibited the least friability and disintegration time 54 seconds along with the rapid release (99.81% drug within 15 min) CP was found to be better suited for the formulation of the fast dissolving tablet of ibuprofen compared to other superdisintegrants used in the study. Stability studies indicated that there are no significant changes in hardness, percentage friability, drug content and in-vitro disintegration time and cumulative percentage drug release (%CDR).


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