alexa Comparative Study on the Efficiency of Various Binder C
e-ISSN:2320-1215 p-ISSN: 2322-0112

Research & Reviews in Pharmacy and Pharmaceutical Sciences
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Research Article

Comparative Study on the Efficiency of Various Binder Combinations for Metformin Tablets

Gunturu Abhilash*, Beny Baby, B Prakash Rao, S Raja Rajan, K Ramesh, and G Ravi Kumar

Karnataka College of Pharmacy, Hedge Nagar Main Road, Bangalore-560064, Karnataka, India.

Corresponding Author: Karnataka College of Pharmacy, Hedge Nagar Main Road, Bangalore-560064, Karnataka, India.

Received date: 15/01/2013 Accepted date: 11/02/2012 Revised date: 08/02/2013

 

 

Abstract

Metformin hydrochloride is widely used as an oral anti hypoglycemic agent. But it is difficult to formulate by direct compression method because of its poor compaction properties and its crystalline nature. The present study target for a better combination of binders that produces metformin tablets with unique results. The granulation is done using binder combination of gelatin, PVP K 30, HPMC, Cross Povidone, starch and Kyron-T 314. The wet granulation method is selected for the formulation of metformin tablets and the formulated tablets were evaluated for their hardness, friability, disintegration, content uniformity and dissolution profiles with USP type II apparatus at 100 rpm in pH 6.8 phosphate buffer solution. The Formulation F2 (containing gelatin and HPMC as binders) demonstrated unique results than the other formulations. The formulation F5 (containing gelatin and Kyron-T 314 as binders) shows faster disintegration than the other formulations but shows least hardness.

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