alexa Comparative Study on the Efficiency of Various Binder C
e-ISSN:2320-1215 p-ISSN: 2322-0112

Research & Reviews in Pharmacy and Pharmaceutical Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Comparative Study on the Efficiency of Various Binder Combinations for Metformin Tablets

Gunturu Abhilash*, Beny Baby, B Prakash Rao, S Raja Rajan, K Ramesh, and G Ravi Kumar

Karnataka College of Pharmacy, Hedge Nagar Main Road, Bangalore-560064, Karnataka, India.

Corresponding Author: Karnataka College of Pharmacy, Hedge Nagar Main Road, Bangalore-560064, Karnataka, India.

Received date: 15/01/2013 Accepted date: 11/02/2012 Revised date: 08/02/2013




Metformin hydrochloride is widely used as an oral anti hypoglycemic agent. But it is difficult to formulate by direct compression method because of its poor compaction properties and its crystalline nature. The present study target for a better combination of binders that produces metformin tablets with unique results. The granulation is done using binder combination of gelatin, PVP K 30, HPMC, Cross Povidone, starch and Kyron-T 314. The wet granulation method is selected for the formulation of metformin tablets and the formulated tablets were evaluated for their hardness, friability, disintegration, content uniformity and dissolution profiles with USP type II apparatus at 100 rpm in pH 6.8 phosphate buffer solution. The Formulation F2 (containing gelatin and HPMC as binders) demonstrated unique results than the other formulations. The formulation F5 (containing gelatin and Kyron-T 314 as binders) shows faster disintegration than the other formulations but shows least hardness.


Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version