alexa Cytotoxic activity of crude and partially purified ink


Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Cytotoxic activity of crude and partially purified ink of L.duvauceli towards HepG2cell line

 
To read the full article Peer-reviewed Article PDF image

Abstract

The present study aims to evaluate the anticancer activity of the crude and partially purified protein fractionated ink of Loligo duvauceli on the Hep G2 cell line using cell viability and cell proliferation assay (MTT assay). Different concentrations of the ink were prepared (125μg, 250μg, 500μg) and the cytotoxic activity was determined. Among the three doses tested, the crude ink of L.duvauceli at the concentration of 500 μg/ml was found to inhibit the viability of the cell effectively and the percentage of viability ranged between 33 – 41. Cells viability decreased with increasing concentrations of the samples. HepG2 cells treated with protein fractionated ink, decreased the percentage of viability and the percentage ranged from 30-49. MTT assay revealed that partially purified ink of L. duvauceli showed higher activity than that of crude ink. The percentage of cell death was 70 in partially purified protein fractionated ink and 67% in crude ink at a concentration of 500μg. IC 50 value was obtained at a concentration of 125μg. The present findings suggest the profound anticarcinogenic activity of partially purified ink of L.duvauceli on HepG2 cancer cell line. Further purified compounds can be used as a potential chemotherapeutic drug for the treatment of Hepatic cancer.

Keywords

Recommended Journals

Share This Page

Additional Info

Loading
Loading Please wait..
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords