alexa Design and Evaluation of a Novel Gas Formation-Based Multiple-Units as a Biphasic Gastro-Retentive Floating Drug Delivery System for Alfuzosin Hydrochloride
e-ISSN:2320-1215 p-ISSN: 2322-0112

Research & Reviews in Pharmacy and Pharmaceutical Sciences
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Research Article

Design and Evaluation of a Novel Gas Formation-Based Multiple-Units as a Biphasic Gastro-Retentive Floating Drug Delivery System for Alfuzosin Hydrochloride

Vinay Kumar Katakam, Sunil Reddy, Jagan Mohan Somagoni, Pavan Kumar Panakanti and Madhusudan Rao Yamsani*

University College of Pharmaceutical Sciences, Kakatiya University, Warangal -506009, Andhra Pradesh, India.

*Corresponding Author:
Madhusudan Rao Yamsani
Vaagdevi group of Pharmacy Colleges
Ram Nagar, Hanamakonda, Warangal - 506 009
Andhra Pradesh, India
Tel.: +91-870-2570543

Received: 23/03/2013 Accepted: 14/04/2013

 

Abstract

A biphasic gastroretentive floating drug delivery system with multiple-unit pellets prepared by extrusion–spheronization process based on gas formation technique was developed for Alfuzosin Hydrochloride to maintain constant plasma level of a drug concentration within the therapeutic window. The system consists of a multiple - unit pellets to be filled into a hard gelatine capsule. The effect of the preparative parameters, e.g., Amount of PR coating on core units, amount of the effervescent agent layered onto the PR coated pellets, and type and coating level of the gas-entrapped polymeric membrane, on the floating ability and drug release properties of the multiple-unit FDDS were evaluated. The system using Eudragit RL30D, Eudragit RS30D and combination of them as polymeric layer could float within acceptable time. The drug release was linear with the square root of time. The rapid floating and the controlled release properties were achieved in this present study. The stability studies of samples showed no significant change in dissolution profiles. In vivo gastric residence time was examined by radiograms, and it was observed that the units remained in the stomach for about 6 h in fed state and stable for 6 months at 40°C/75% RH.

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