Design and Evaluation of Solubility Enhancement of Poorly Soluble Drugs using Liquid Solid Compacts
Oral dosage form is the physical form of a dose of a chemical compound used as a drug or medication intended for administration or consumption by the oral route. The poor dissolution rate of water insoluble drugs is still a substantial problem confronting the pharmaceutical industry. There are several methods used to increase the solubility of drugs, of those liquid-solid compact (LSC) technique is a new and promising addition towards such a novel aim, that the solubility of the insoluble drug moiety is increased by aid of non-volatile solvents and hence increasing the dissolution and bioavailability. LSC’s when compared to all other standard methods used to improve the solubility, have more ability to enhance solubility. Liquisolid compacts were prepared by employing non-volatile solvents like- Polyethylene Glycol and Propylene Glycol, whereas microcrystalline cellulose (MCC) and Aerosil were used as carrier and coating materials, respectively. Disintegrants were used from 2% to 4% to ensure the immediate release of the drug and in turn achieve maximum peak plasma concentration. Magnesium Stearate acted as both glidant and lubricant added prior to compression of tablets. In-vitro drug release results showed that Liqui-solid compacts demonstrated significantly higher drug release rates in less time than those of conventionally made. This was due to an increase in wetting properties and surface of drug available for dissolution.