alexa Development and Validation of Simultaneous Estimation o
e-ISSN:2320-1215 p-ISSN: 2322-0112

Research & Reviews in Pharmacy and Pharmaceutical Sciences
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Research Article

Development and Validation of Simultaneous Estimation of Paracetamol and Pamabrom in Bulk and Combined Pharmaceutical Dosage Form by RP-HPLC.

S Dhruvi*, B Ankita, and P Bhagirath

Sat Kaival College of Pharmacy, Sarsa-388365, Ta. Dist. Anand, Gujarat, India.

 

*Corresponding Author:
Sat Kaival College of Pharmacy, Sarsa-388365, Ta. Dist. Anand, Gujarat, India.
Mobile: +91 9909446944

Received date: 13/02/2014 Accepted date: 17/03/2014 Revised date: 12/03/2014

 

 

Abstract

A simple, rapid and precise Reverse Phase High Performance Liquid Chromatography (RP-HPLC) method was developed for simultaneous estimation of paracetamol and pamabrom in bulk and combined pharmaceutical dosage form by using BDS hypersil C18 column. The sample was analysed using phosphate buffer (pH-4): methanol (65:35v/v) as a mobile phase at a flow rate of 1.0 ml/min and detected at 270 nm. The retention time for paracetamol and pamabrom was found to be 4.04 min and 7.36 min respectively. The linearity of developed method was achieved in the range of 32.5-97.5μg/ml for paracetamol and 2.5-7.5μg/ml for pamabrom. The method was validated in terms of accuracy, precision, linearity, limit of detection, limit of quantitation and robustness as per International Conference Harmonization (ICH) guidelines.

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